Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 51 0.0 0.468 0.029 0.082
biological_process el 51 0.09 0.971 0.67 0.278
biological_process ka 51 0.0 0.422 0.027 0.075
biological_process rf 51 0.0 0.468 0.029 0.082
cellular_component ct 4 0.0 0.169 0.045 0.072
cellular_component el 4 0.009 0.283 0.121 0.11
cellular_component ka 4 0.001 0.188 0.053 0.078
cellular_component rf 4 0.0 0.169 0.045 0.072
disease ct 13 0.001 0.847 0.172 0.251
disease el 13 0.189 0.858 0.563 0.206
disease ka 13 0.0 0.943 0.19 0.282
disease rf 13 0.001 0.847 0.172 0.251
genetic_interaction ct 47 0.0 1.0 0.389 0.332
genetic_interaction el 47 0.0 1.0 0.418 0.347
genetic_interaction ka 47 0.0 1.0 0.915 0.279
genetic_interaction rf 47 0.0 1.0 0.407 0.342
molecular_function ct 33 0.0 0.19 0.009 0.034
molecular_function el 33 0.006 0.843 0.427 0.272
molecular_function ka 33 0.0 0.219 0.01 0.039
molecular_function rf 33 0.0 0.19 0.009 0.034
pathway ct 26 0.001 0.996 0.062 0.19
pathway el 26 0.001 0.207 0.02 0.042
pathway ka 26 0.001 1.0 0.273 0.441
pathway rf 26 0.001 0.168 0.022 0.039
phenotype ct 13 0.0 0.912 0.303 0.323
phenotype el 13 0.026 0.859 0.473 0.279
phenotype ka 13 0.0 1.0 0.353 0.372
phenotype rf 13 0.0 0.907 0.303 0.323
protein_interaction ct 53 0.0 0.741 0.024 0.105
protein_interaction el 53 0.0 0.779 0.027 0.111
protein_interaction ka 53 0.001 1.0 0.214 0.402
protein_interaction rf 53 0.0 0.74 0.023 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 53 0.0 0.681 0.057 0.126
integration_mean_by_presence el 53 0.0 0.85 0.061 0.153
integration_mean_by_presence ka 53 0.0 0.541 0.042 0.121
integration_mean_by_presence rf 53 0.0 0.297 0.021 0.054
mean ct 53 0.0 0.68 0.087 0.191
mean el 53 0.0 0.387 0.05 0.109
mean ka 53 0.0 0.532 0.048 0.124
mean rf 53 0.0 0.281 0.028 0.067

CDF plots of non integrated kernels

CDF plots of integrated kernels